Glutamine is the most abundant non-essential amino acid in the body. Its importance in the functioning of multiple organs has been clearly demonstrated. Due to its abundance and endogenous synthesis, glutamine is considered a non-essential amino acid. It acts as a precursor for protein synthesis and also participates in numerous metabolic pathways. In situations of stress, the acceleration of proteolysis and the increased needs of various organs (liver, intestine, immune system) deplete the glutamine stock in skeletal muscle. This deficit limits the capacity to respond to metabolic stress, the optimal functioning of certain tissues, and negatively influences clinical outcomes.